Journal of microbiology, epidemiology and immunobiologyJournal of microbiology, epidemiology and immunobiologyЖурнал микробиологии, эпидемиологии и иммунобиологии0372-93112686-7613Central Research Institute for Epidemiology13289ArticlesСтатьиReview ArticleCHRONIC HEPATITIS B AND PROBLEM OF VIRAL PERSISTENCE FROM POSITION OF DISEASE'S IMMUNOPATHOGENESISХРОНИЧЕСКИЙ ГЕПАТИТ В И ПРОБЛЕМА ПЕРСИСТЕНЦИИ ВИРУСА С ПОЗИЦИЙ ИММУНОПАТОГЕНЕЗА ЗАБОЛЕВАНИЯSemenenkoT. AСемененкоТ. АGamaleya Research Institute of Epidemiology and Microbiology, Moscow, RussiaНИИ эпидемиологии и микробиологии им. Н.Ф.Гамалеи, Москва15082009864NO4 (2009)№4 (2009)333909062023Copyright ©; 2009, Semenenko T.A.Copyright ©; 2009, Семененко Т.А.2009Semenenko T.A.Семененко Т.А.https://creativecommons.org/licenses/by/4.0https://microbiol.crie.ru/jour/article/view/13289

Results of recent studies on the problem of hepatitis B virus (HBV) persistence are presented in this review. Different mechanisms of development of chronic form of infection from position of its immunopathogenesis are reviewed. Data obtained in studies of genetic properties of HBV and emergence of its mutant forms as well as significance of apoptosis as a fundamental process of homeostasis, role of HLA-restricted T-cell response and cytokines for resolved and persistent form of infection caused by HBV are discussed.

В обзоре представлены результаты последних исследований, касающихся проблемы персистенции вируса гепатита В. Рассмотрены различные механизмы формирования хронической формы инфекции с позиции иммунопатогенеза заболевания. Обсуждаются данные, полученные при изучении генетических особенностей вируса гепатита В и формирования его мутантных форм, значение апоптоза как фундаментального процесса гомеостаза, роль HLA-рестриктированного Т-клеточного ответа и цитокинов при разрешившейся и персистентной форме инфекции, вызванной вирусом гепатита В.

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